Modiano, a professor in the University of Minnesota College of Veterinary Medicine and director of the university?s Animal Cancer Care and Research program, will join collaborators Matthew Breen, Ph.D., of North Carolina State University, and Kerstin Lindblad-Toh, Ph.D., of the Broad Institute of MIT and Harvard, in refining the current understanding of why golden retrievers are more susceptible to two hemangiosarcoma and lymphoma cancers than other dog breeds.
?We want to investigate which combinations of heritable traits make these dogs more prone to cancers than other dog breeds,? said Modiano. ?After we understand the source of the problem, we can begin to understand what to do to prevent the cancer in the first place.?
Interestingly, canine and human tumors are often nearly clinically identical, making treatments and diagnostics that work for dogs potentially translatable to humans. Additionally, the understanding of lymphoma or hemangiosarcoma that might take five years to develop by observing a human patient might be understood in less than one year in a canine patient, because cancer?s progression is accelerating in a relatively shorter canine lifespan.
?To best help dogs and humans, we have to determine which of our findings are dog-specific and which are human-specific,? said Modiano, ?and where the links are between the two universes.?
About the University of Minnesota College of Veterinary Medicine
The College of Veterinary Medicine improves the health and well-being of animals and people by providing high-quality veterinary training, conducting leading-edge research, and delivering innovative veterinary services.
About the Masonic Cancer Center
The Masonic Cancer Center at the University of Minnesota is part of the University's Academic Health Center and is designated a Comprehensive Cancer Center by the National Cancer Institute for cancer research, treatment, and education. For more information about the Masonic Cancer Center, visit or call 612-624-2620.
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